IBS Treatment Medications Diarrhea medicines: Medicines that may be used to treat severe diarrhea that does not improve with home treatment include:
  • Antidiarrheals, including atropine and diphenoxylate (such as Lomotil) and loperamide (such as Imodium).
  • Bile acid binding agents, including cholestyramine (such as Prevalite).

  • Rifaximin (Xifaxan), which has been shown to help people who have diarrhea and bloating as their worst symptoms. Rifaximin can be taken for 14 days. People who have symptoms again can be retreated for 14 days. This can be done one more time if needed.5
  • Alosetron (Lotronex), which is used for some women who have severe diarrhea. This medicine has been shown to contribute to ischemic bowel disease. Specific guidelines for the use of alosetron require doctors who prescribe it to sign a certificate and patients to sign a consent form.

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